CM Protégé PharmD System

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There is an increasing expectation that scientists explore a broader experimental space to identify both the most druggable form of an active pharmaceutical ingredient (API) and the best process to synthesize it. With companies facing material and resource limitations, the increased productivity of automated research systems can have a significant impact. Freeslate’s CM Protégé PharmD System is a versatile automated solid form, solubility, and process chemistry screening system tailored for today’s fast-paced drug development environment.

The standard system performs high throughput polymorph, salt, co-crystal, and solubility screens of API. The deck of the CM Protégé PharmD System has independent Heating/Cooling/Stirring stations to precisely control the temperature of your experiments while mixing. Solutions are transferred and filtered using the system’s unique Heated 4-Tip Liquid Dispenser and 96-well Heated Filter Block. Both can be heated up to 120 °C, allowing transfer and filtration of saturated solutions at elevated temperatures without the risk of API precipitation. Using Freeslate’s proprietary Crystallization Assembly with Universal Substrate, solid forms can be separately analyzed by birefringence, x-ray powder diffraction (XRPD), and Raman spectroscopy directly without any manual manipulation of fragile crystals. The CM Protégé PharmD System uses Freeslate’s powerful Lab Execution and Analysis (LEA) software for library design, execution, data analysis, and reporting, allowing experimental conditions to be linked to analytical data for easy viewing and reporting.

Reaction Screening Option for the CM Protégé PharmD System: By introducing a Vortexing Station and adding a Heated 1-Tip Liquid Dispenser, the system can screen up to 96 reactions in parallel, including those that require handling slurries. By performing such a large number of reactions in parallel, discrete variables like solvents, ligands, catalysts, reagents, and reagent combinations can be rapidly screened to identify the parameters that have the biggest impact on your chemistry. For pressure chemistry, an optional On-Deck HiP Reactor rated at 200 psi and 180 °C is available.

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